MDAI Combinations

[woppachew]

would be interested in a few more mdai/3fpm reports but i think for now il swap out the mpa for straight mephylphediate and see how it goes.

[Xochipilli]

Bit of a problem for 50% or so of the respondents if MPA is gone - I have MDAI left but almost no MPA - going on exerience 4F-MPh is likely going to sit well with me and for some reason I don't trust 3F-PM as far as I can throw it - breif euphoria and feel just awful - short of an MPA analog poping up soon (assuming similar effects) what are the MPA-ers going to do? Phenidates or did everyone stock up?

[niamh]

I'm planning to give 4F-EPH a go with this. I think the higher potency and serotonergic feeling of the 4F phenidates may be to do with different and increased activity at VMAT. Since VMAT2 antagonism is another slice of MDMA activity that MDAI lacks this could be interesting. It would explain the redose and timing sensitive synergy I sometimes get with 4F-MPH as a combination. With 4F-EPH I'll be slowly titrating my doses because although I doubt serotonin syndrome is likely risk, there's enough unknowns that I wouldn't rule it out. So if anyone else has had the same idea, please be cautious and don't jump in with a high dose.

[Jonnyhal]

Intrested to hear your results with 4f-eph when you get around to it

[niamh]

300mg MDAI + 40mg 4F-EPH

Having sampled this combination at lower doses with typical MDAI + stimulant effects and no signs of any danger, I decided to push the dosage a little higher. This is partially motivated by having found occasional unpredictable synergy between 4F-MPH and MDAI, with the hope that more predictable synergistic effects might be found with the ethyl ester.

I took the MDAI first and then shortly afterwards dosed the 4F-EPH (I'd used some earlier in the day, so this was actually a re-dose, which may or may not be relevant. Doses were weighed. The MDAI was parachuted while I insufflated the 4F-EPH.

I felt the 4F-EPH first, with the stimulant effects building and being joined by the familiar MDAI entactogenic feeling. I've dosed up to 45mg with 4F-EPH so I knew what to expect from the stimulant. The MDAI built quickly and just kept on going, far past the point I'd expect it to plateau. A high-energy euphoria with a very physical aspect to it. As it peaked I had to lie back on my sofa and let the waves of feeling wash over me. This was what I'd been hoping to find and then some, another incremental step on from the two or three 4F-MMPH/MDAI experiences that have really worked. As I adjusted to life in a universe that loved me unconditionally and wasn't afraid to show it, my eyes - two wine-dark seas with only a sliver of iris remaining at the periphery - started to wiggle around. I'm sure I looked completely and utterly off my face. It was awesome. Never having tried the controlled drug that this combination is clearly intended as an analogue of, it's hard to say how close this comes to replicating the effects. Whether it did or didn't, the pleasure centres of my brain were clearly bathed in something they liked.

Peak effects continued for 4 hours or so, with effects gradually wearing off afterwards leaving an afterglow. Pupils were back to their constricted normal by 7 hours after dosing. Over the next day, further doses of 4F-EPH echoed the feeling. No come-down effects were noted aside from reduced appetite and a slight tendency towards nystagmus continuing over the next day or two.

Whether this effect is more predictable than similar experiences with 4F-MPH isn't clear yet. It's also important to recognise that this combination may well be higher risk than others. We know so little about the pharmacology of 4F-EPH and don't know what mechanism lies behind this synergistic effect (my guess - increased/altered activity at VMAT2 and/or increased/less specific 5-HT activation) that it's hard to know where to begin with evaluating the safety and risks of the combination. Serotonin syndrome could be a potential issue and is likely to be a more significant risk if further substances are involved compared to MDAI alone or in less synergistic combinations.

[ralhar]

Thank you niff... where did you obtain your materials?

Thanks.

[Ozle]

Is MDAI without a stimulant a good anxiolytic? It seems some people say it calms them down, while others find it stimulating eve without adding anything else.

[niamh]

Is MDAI without a stimulant a good anxiolytic? It seems some people say it calms them down, while others find it stimulating eve without adding anything else.

WHat do you mean by 'good anxiolytic'? It has a lot of non-anxiolytic properties in addition to possible mild sedation and that would generally be considered to be a bad thing in a (non-recreational) drug. Generally speaking, euphoria is considered a bad thing in functional drugs. It's not something that you'd want to take as an anxiety treatment because its other effects are too noticeable.

[Ozle]

I was imagining something similar to banzos without the sedation or loss of judgement. If does makes you euphoric even at lose doses it's likely not something I could ever see myself taking daily for college.

I have some issues with public speaking, even when it's just summarising my dissertation to a professor at the beginning of term, or presenting to a panel an outline of the project I'm meant to be undertaking and producing concrete results for by the end of this semester.

Then again, phenibut already does a great job of managing situations like that.

[niamh]

I was imagining something similar to banzos without the sedation or loss of judgement. If does makes you euphoric even at lose doses it's likely not something I could ever see myself taking daily for college.

I have some issues with public speaking, even when it's just summarising my dissertation to a professor at the beginning of term, or presenting to a panel an outline of the project I'm meant to be undertaking and producing concrete results for by the end of this semester.

Then again, phenibut already does a great job of managing situations like that.

It's not something anyone should be taking daily. Any anxiolytic effects are likley to be downstream effects of serotonin release and repeated use (even at low dose) wil deplete your serotonin quickly.

You're at college - this is the best time to learn how to deal with your nerves around public speaking. Lots of people have problems with this, and (really) the solution is to keep doing it in spite of the anxiety and learn not to care if you screw up. College is a low-consequence environment where imperfection is expected because you're still being educated. Drugs can help with anxiety, but they don't teach you anything. The only way out is through. You have to experience the anxiety in order to learn how to deal with it. Spending the time and effort now is genuinely an investment that will pay off later.

Anxiety is just a signal your brain produces when it senses danger. You can't control the emotional signals that your brain presents to you (at least not in the short term), but you can choose how you respond to them; it's not always easy but it's a skill you can develop and get better at. Have a look at cognitive behavioural therapy and mindfulness techniques. Colleges often provide counselling services for students which may also be helpful.