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300mg MDAI + 40mg 4F-EPH
Having sampled this combination at lower doses with typical MDAI + stimulant effects and no signs of any danger, I decided to push the dosage a little higher. This is partially motivated by having found occasional unpredictable synergy between 4F-MPH and MDAI, with the hope that more predictable synergistic effects might be found with the ethyl ester.
I took the MDAI first and then shortly afterwards dosed the 4F-EPH (I'd used some earlier in the day, so this was actually a re-dose, which may or may not be relevant. Doses were weighed. The MDAI was parachuted while I insufflated the 4F-EPH.
I felt the 4F-EPH first, with the stimulant effects building and being joined by the familiar MDAI entactogenic feeling. I've dosed up to 45mg with 4F-EPH so I knew what to expect from the stimulant. The MDAI built quickly and just kept on going, far past the point I'd expect it to plateau. A high-energy euphoria with a very physical aspect to it. As it peaked I had to lie back on my sofa and let the waves of feeling wash over me. This was what I'd been hoping to find and then some, another incremental step on from the two or three 4F-MMPH/MDAI experiences that have really worked. As I adjusted to life in a universe that loved me unconditionally and wasn't afraid to show it, my eyes - two wine-dark seas with only a sliver of iris remaining at the periphery - started to wiggle around. I'm sure I looked completely and utterly off my face. It was awesome. Never having tried the controlled drug that this combination is clearly intended as an analogue of, it's hard to say how close this comes to replicating the effects. Whether it did or didn't, the pleasure centres of my brain were clearly bathed in something they liked.
Peak effects continued for 4 hours or so, with effects gradually wearing off afterwards leaving an afterglow. Pupils were back to their constricted normal by 7 hours after dosing. Over the next day, further doses of 4F-EPH echoed the feeling. No come-down effects were noted aside from reduced appetite and a slight tendency towards nystagmus continuing over the next day or two.
Whether this effect is more predictable than similar experiences with 4F-MPH isn't clear yet. It's also important to recognise that this combination may well be higher risk than others. We know so little about the pharmacology of 4F-EPH and don't know what mechanism lies behind this synergistic effect (my guess - increased/altered activity at VMAT2 and/or increased/less specific 5-HT activation) that it's hard to know where to begin with evaluating the safety and risks of the combination. Serotonin syndrome could be a potential issue and is likely to be a more significant risk if further substances are involved compared to MDAI alone or in less synergistic combinations.