Yes the wild lettuce is a curious one; never tried it though - didn't know about its use in the Victorian era but no surprise I guess; being mildly smashed has a long history before anyone got all in a tizzy over it. As for the vicar no great deal. Of course everyone from kids up drank beer way back and monks brewed beer; and actually organised great village wide week long benders as I recall to get funds.
I am being skeptical about placebo effects and so on but certainly not outright distrusting anything and await results. Not had huge luck with most herbs though swear by ginger for nausea - most are mild, highly active ones like poppy/digitalis are banned or medicalised. NHS still prescribes peppermint oil (colpermin) - it didn't help me but if you can treat things with the mildest thing possible it's no bad thing. I can't point to real evidence for 5HTP beyond experience but of course that's botanically sourced.
"Do what thou wilt shall be the whole of the law"