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Apppreciate peoples genuine thoughts on this please
#41
My first instinct is that 1000mg 5-HTP is WAYY too much.

Secondly, 5-HTP really needs to be a post-roll supplement as there are risks associated with taking it alongside MDMA.

The antioxidants need to be taken before the MDMA.

(20-11-2014, 06:07 PM)TKK Wrote: 5-HTP, like Prozac, needs to taken regularly over approximately three weeks to gain any potential benefit.
For normal indications what you have said is true but for attenuating MDMA neurotoxicity it is not - immediately after MDMA use is optimal, though prozac and 5-HTP have very different mechanisms for their protective effects in these cases. Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan


(20-11-2014, 06:32 PM)Kingbuyer Wrote: The reason i don't believe the antioxidant will work is because i remember reading a study like this one where asorbic acid was given to rats the amount necessary to protect from MDMA nerotoxity would destroy you stomach. Link
Vitamin C is a good antioxidant but its high water solubility makes it less suitable for entering the brain to deal with MDMA neurotoxicity. ALA is better for this reason but it still has a short half life.

There are some great literature reviews on reddit on this topic, well worth a read:
https://www.reddit.com/r/Borax/comments/...otoxicity/
https://www.reddit.com/r/DrugNerds/comme...tabolites/
https://www.reddit.com/r/DrugNerds/comme...ementation

The "RaveAid" product has already cornered the market for this type of product in north america.
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#42
Taking 5HTP after MDMA is a bad idea as the comedown is caused by serotonin downregulation, increasing serotonin levels will only make this worse or delay recovery, maybe help in the short term.

In contrast to popular beleive, mdma does not deplete serotonin, thats just a measure of neurotoxiticy.
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#43
What would 5htp be good for then
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#44
Well it would temporary alleviate the day after depression but it would further downregulate the serotonin receptors which was the cause of the depression in the first place, in the long run this would lead to problems.

Also if you use it daily for depression you can develop heart problems in the long run.
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#45
I wouldn't buy it. I already get 90% of those ingredients in a multivitamin. A roll pack shoulds be a bottle of water a test kit and a multivitamin.
So mabey a roll drink be made, lol. Rolleraide, packed with antioxidants.
love the world and it will love you back. chin
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#46
Facepalm
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Need to e-mail me?
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#47
What's wrong with rolleraide? Add some caffeine make it like red bull or something.lol
love the world and it will love you back. chin
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#48
(09-04-2016, 11:52 AM)Alias22 Wrote: Taking 5HTP after MDMA is a bad idea as the comedown is caused by serotonin downregulation, increasing serotonin levels will only make this worse or delay recovery, maybe help in the short term.

In contrast to popular beleive, mdma does not deplete serotonin, thats just a measure of neurotoxiticy.


I partly agree. Mild neurotoxicity and the subsequent repair of oxidative damage to serotonin-associated neurones seems much more likely to me than depletion of serotonin stores as a mechanism for the comedown syndrome (which non-neurotoxic serotonin releasers seem to lack).

It's possible that 5-HTP has meaningful effects not by its action on serotonin (single or very brief doses seem unlikely to result in any significant down-regulation of 5-HT receptors) but by reducing the level of dopamine in the brain. Both 5-HTP and dopamine's immediate precursors, phenylalanine and tyrosine are converted into the neurotransmitters by the same enzyme (AAAH) which means that higher levels of 5-HTP will result in more of that bound to the enzyme as it's converted, reducing the amount available (and therefore the rate of conversion) for dopamine. As high levels of dopamine and its breakdown products are heavily implicated in MDMA neurotoxicity, it's possible that any perceived positives of 5-HTP are down to slowed re-uptake of dopamine and less oxidative damage as a result.

That's just some speculation, but I think it's plausible. Overall, I don't think 5-HTP should be regarded uncritically, but probably isn't harmful if used in a limited way. And yeah, people who think it's as simple as refilling a fuel tank are wrong.
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#49
Tried 5HTP a fair bit and it seem to help a lot. It’s true there is evidence of down regulation of serotonin with chronic high doses but I was also going to say I am a bit doubtful about it with in the short term with sensible doses. In the wake of something like MDMA given modration food and sleep etc I have never experienced depression the next day, more like 3 days on and taking 5HTP for a period of 3-5 days following empathogen exposure has seemed very effective and there have been no notable causing worse effects in the long run since it has only been to tide over this period.
It’s true that long term use could in theory cause fibrosis but not sure it’s ever been shown in practise and it is also true of lots of psychedelics, stims and medicines and any form of raised blood levels of Serotonin including normal treatment for depression. It was a rare effect of fenfluramine but certainly serious enough one might want to consider it when taking any such drugs or 5HTP it’s self on a regular basis but also there are a lot of unanswered questions as to the actual level of risk.
I have found 5HTP also seems fairly effective in lessening insomnia.
"Do what thou wilt shall be the whole of the law"
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