25-10-2012, 02:10 AM
(This post was last modified: 25-10-2012, 02:18 AM by Sepher.)
It depends on the type of drug and the type of anti-d xenon. I'm not a chemist / pharmacologist so this is all lay-man stuff but SSRIs/SNRI's like Prozac or Mirtazipine would tend to block your serotonergics from working properly, so psychedelics or stimulants that act mainly on serotonin receptors would be a waste of time. Mirtazipine quite successfully blocked 1.1mg of 25I-NBOMe for example, leaving me with only threshold effects. Take a serotonergic on an MAOI type anti-d though or an MAOI on a serotonergic anti-d you could be in a lot of trouble, serotonin syndrome territory, potentially fatal. I'm not sure if this was the cause of a seriously bat-shit mental incident I had with aMT, that being a weak MAOI interacting with Mirtazipine again?
Lots of drugs act as direct agonists of several types of receptor or as releasers of several types of neurotransmitter, cocaine acting on dopamine, serotonin and noradrenaline for example. Depending on the anti-d you may get attenuation of some effects or potentiation of others altering the usual balance of effects they give you. This could certainly be problematic, the possibility is there at least. Even opiates can be affected because some inhibit CYP450 cytochrome enzymes responsible for metabolisation, SSRI inhibition of CYP2D6 enzymes responsible for codeine conversion for instance. Not dangerous there but pretty pointless. In short it's not wise to take drugs of any description when you're on anti-ds really without first really doing your homework, if at all.